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Rislenemdaz mesylate
CAS No. 1893392-76-1
Rislenemdaz mesylate( MK 0657 | CERC 301 )
Catalog No. M12971 CAS No. 1893392-76-1
Rislenemdaz (MK 0657;CERC 301) is a potent, orally bioavailable, brain‐penetrant, NR2B-selective NMDA receptor (GluN2B) antagonist with Ki and IC 50 of 8.1 nM and 3.6 nM respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
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Biological Information
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Product NameRislenemdaz mesylate
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NoteResearch use only, not for human use.
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Brief DescriptionRislenemdaz (MK 0657;CERC 301) is a potent, orally bioavailable, brain‐penetrant, NR2B-selective NMDA receptor (GluN2B) antagonist with Ki and IC 50 of 8.1 nM and 3.6 nM respectively.
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DescriptionRislenemdaz (MK 0657;CERC 301) is a potent, orally bioavailable, brain‐penetrant, NR2B-selective NMDA receptor (GluN2B) antagonist with Ki and IC 50 of 8.1 nM and 3.6 nM respectively, with no off-target activity; inhibits calcium influx into agonist‐stimulated NMDA‐GluN1a/GluN2B L(tk‐) cells with IC50 of 3.6 nM, with no effect on GluN2A up to 30 uM; significantly decreases immobility frequency and increases swimming behavior in acute depression models.Depression Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsMK 0657 | CERC 301
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PathwayMembrane Transporter/Ion Channel
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TargetiGluR
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RecptoriGluR
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Research AreaNeurological Disease
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IndicationDepression
Chemical Information
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CAS Number1893392-76-1
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Formula Weight454.517
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Molecular FormulaC20H27FN4O5S
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name4-methylbenzyl (3S,4R)-3-fluoro-4-((pyrimidin-2-ylamino)methyl)piperidine-1-carboxylate mesylate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Addy C, et al. J Clin Pharmacol. 2009 Jul;49(7):856-64.
2. Ibrahim L, et al. J Clin Psychopharmacol. 2012 Aug;32(4):551-7.
3. Garner R, et al. Pharmacol Res Perspect. 2015 Dec 23;3(6):e00198.
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